1600 IU daily Vitamin D raised adult blood levels above 20 ng – RCT Nov 2011

Is a daily supplementation with 40 microgram vitamin D(3) sufficient? A randomised controlled trial.

Eur J Nutr. 2011 Nov 16.
Toss G, Magnusson P.
Department of Endocrinology and Gastroenterology, County Council of Östergötland, SE-581 85, Linköping, Sweden.

PURPOSE: The effect of 40 ug (1,600 IU) per day of vitamin D(3) on serum 25-hydroxyvitamin D (25(OH)D) and markers of bone and mineral metabolism was evaluated.

METHODS:This intervention study was designed as a double-blind randomised controlled trial. Forty-five community-dwelling subjects (32 females), age 55-84 years, at 58° North latitude were supplemented for 1 year with 40 ug vitamin D(3) plus 1,000 mg calcium per day, or with 1,000 mg calcium per day for controls. Safety parameters and 25(OH)D, intact parathyroid hormone (PTH), ionized calcium, bone-specific alkaline phosphatase (BALP), and tartrate-resistant acid phosphatase isoform 5b (TRACP5b) were measured over the study period.

RESULTS: All subjects supplemented with vitamin D(3) reached a 25(OH)D level above 50 nmol/L.
Mean (SD) serum 25(OH)D increased from 50.4 (13.5) nmol/L to 84.2 (17.5) nmol/L, range 55.0-125.0 nmol/L in the vitamin D(3) supplemented group and the corresponding levels for the control group were 47.3 (14.1) nmol/L and 45.7 (13.4) nmol/L, range 26.0-73.0 nmol/L.

No serious adverse event was recorded and the highest 25(OH)D level reached, 125.0 nmol/L, is well below toxic levels. BALP and TRACP5b did not change significantly over the study period.

CONCLUSIONS: This trial suggests that a daily supplementation with 40 ?g vitamin D(3) is sufficient to secure a 25(OH)D level of 50 nmol/L.
No side effects were observed in the study group.

PMID: 22086300

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Summary by VitaminDWiki

1600 IU vitamin D daily with Calcium were given to community-dwelling seniors

	Initial	Final
Average	20 ng	34 ng
Everyone above		20 ng
Highest		50 ng

See also VitaminDWiki

• All items in How Much Vitamin D 345 items
• 2000 IU of vitamin D is a step in the right direction for Canada– Nov 2010
• Four reasons why vitamin D levels should be higher the 30 ng – Aug 2011
• Cadavers with good skeletons had 30 ng of vitamin D – Feb 2010
• Intervention - add vitamin D and see what happens
• Overview How Much vitamin D which includes the following

Everyone older than 11 years should be taking AT LEAST 2000 IU of vitamin D daily everywhere around the world
I realize that the 2010 US standard specifies a minimum of 400 or 600 IU. But, the that is like a minimum wage - very difficult to live on
The US and the European Union both currently have an Upper Limit of 2000 IU which will probably be revised upward in late 2010.

You can see in the following chart, 20ng does not reduce the probability of any disease except rickets

• CLICK HERE for larger image and more charts of disease incidence